In areas where malaria is endemic, sickle cell disease heterozygote carriers are less fit than individuals homozygous for the normal allele.

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In areas where malaria is endemic, sickle cell disease heterozygote carriers actually have a fitness advantage over individuals homozygous for the normal allele. This is because the sickle cell trait provides some protection against malaria.

In Areas Where Malaria Is Endemic, Sickle Cell Disease Heterozygote