A 2-year-old child known to suffer from recurrent bacterial infections and poor wound healing was found to have leukocyte adhesion molecule deficiency 1 (LAD-1). The leukocytes of this patient do not express CD18, a molecule classified as belonging to the family of

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LAD-1 is characterized by a deficiency of CD18, a cell surface molecule that is a ß₂ integrin. The infections occur because the defective leukocytes cannot adhere to endothelial cells, cannot spread and attach, and cannot phagocytose bacteria.

A 2-Year-Old Child Known to Suffer from Recurrent Bacterial Infections