Homogeneous staining regions (HSR) of chromosome 2p, the site of the N-mycgene, are adverse prognostic signs if found in neuroblastoma cells. HRS are evidence of gene

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Homogeneous staining regions and double minutes are signs of gene amplification. Amplification of the N-myc oncogene in neuroblastoma cells is a poor prognostic finding.

Homogeneous Staining Regions (HSR) of Chromosome 2p, the Site of the N-Mycgene