Mycobacterium tuberculosis phagocytosed by macrophages in granulomas can be killed by endogenous nitric oxide (NO) after these macrophages become activated by T-helper cells. Which biologically active substance stimulates the formation of NO in macrophages?

Question

Quizplus · Accepted Answer

CD4+ T-helper cells secrete interferon-g, which stimulates the macrophages to produce nitric oxide (NO), NO₂, and HNO₃. These bactericidal substances kill the tubercle bacilli in the cytoplasmic vacuoles of the macrophages.

Mycobacterium Tuberculosis Phagocytosed by Macrophages in Granulomas Can Be Killed