Aplastic crisis, which can be encountered in patients with hereditary spherocytosis or sickle cell anemia, is most often precipitated by
A) deficiency of erythropoietin
B) negative feedback inhibition by bilirubin
C) adverse effect of iron released from hemolyzed erythrocytes
D) autoimmune mechanisms
E) parvovirus infection

Question

Quizplus · Accepted Answer

Aplastic crisis in hereditary spherocytosis or sickle cell anemia is usually triggered by parvovirus infection. The virus infects and destroys the red blood cell precursors in the bone marrow.

Aplastic Crisis, Which Can Be Encountered in Patients with Hereditary