Compression fractures of vertebral bodies seen in elderly women are causally related to reduced recruitment of osteoclasts. This process is associated with an increased concentration of which chemical mediators in the bone?
A) Prostaglandins
B) Leukotrienes
C) Cytokines such as interleukin (I
L)-1 and IL-6
D) Oncogenes such as c-MYC and K-RAS
E) Fibroblast growth factors

Question

Compression fractures of vertebral bodies seen in elderly women are causally related to reduced recruitment of osteoclasts. This process is associated with an increased concentration of which chemical mediators in the bone? 
A) Prostaglandins 
B) Leukotrienes 
C) Cytokines such as interleukin (I
L)-1 and IL-6 
D) Oncogenes such as c-MYC and K-RAS 
E) Fibroblast growth factors

Quizplus · Accepted Answer

Compression fractures of vertebral bones in postmenopausal women are related to reduced levels of estrogens. Reduced levels of estrogen lead to an increase of cytokines, such as interleukin (IL)-1 and IL-6, which retard the recruitment of monocytes to the bones and inhibit their transformation into osteoclasts (a process known as osteoclast recruitment).

Compression Fractures of Vertebral Bodies Seen in Elderly Women Are