Propranolol (Inderal)is eliminated almost entirely via metabolism by the liver after oral administration.This necessitates giving much larger doses by mouth as compared to intravenous (IV)administration.For this reason,propranolol is a good example of a drug that exhibits which of the following effects?

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Many medications undergo significant biotransformation as they are broken down into smaller usable parts,primarily in the liver,through a series of complex chemical reactions.When most of a medicine goes very quickly to the liver,a great deal of medication is inactivated on its "first pass" through the liver.This significant "first-pass" effect with propranolol accounts for an oral dose of 40 mg being equivalent to an intravenous dose of only 1 mg.

Propranolol (Inderal)is Eliminated Almost Entirely Via Metabolism by the Liver