Selectins differ from integrins in which one of the following ways?
A)Selectins are expressed only on endothelial cells and integrins are expressed only on leukocytes.
B)Selectins are important mediators of leukocyte adhesion to endothelium,but integrins are not.
C)Selectins bind carbohydrate ligands,but integrins do not.
D)Selectins mediate rolling of leukocytes on endothelium,but integrins do not.
E)Selectins are a family of homologous molecules,but integrins are not.

Question

Quizplus · Accepted Answer

Selectins specifically bind carbohydrate groups on cell surface glycoproteins,whereas integrins do not bind carbohydrate groups on Ig superfamily molecules.L-selectin and several integrins are both expressed on some lymphocytes.Both selectins and integrins are important mediators of leukocyte adhesion to endothelium.Both selectins and integrins (especially VLA-4)can mediate rolling interactions;selectins are more specialized in this regard.There are three members of the selectin family (E-,P-,and L-)and more than 30 different members of the integrin family.

Selectins Differ from Integrins in Which One of the Following