All of the following are early T cell events that occur after antigen recognition by the TCR EXCEPT:
A)Formation of the immunologic synapse
B)Recruitment of signaling molecules,such as LAT,to glycolipid-enriched domains known as lipid rafts
C)Enhanced adhesion between T cells and antigen-presenting cells (APCs)via T cell integrin LFA-1 and its ligand on the APC,ICAM-1,at the central zone of the immunologic synapse
D)Clustering of the TCR and coreceptors leading to phosphorylation of ITAMs on CD3 by Lck
E)Binding of CD28 with costimulators on APCs in the cSMAC,resulting in signal transduction activation

Question

Quizplus · Accepted Answer

On binding of the TCR complex with MHC-associated peptides on an antigen-presenting cell (APC),several T cell surface proteins and intracellular signaling molecules are rapidly mobilized to the site of contact,known as the immunologic synapse.Molecules that are recruited to the central supramolecular activation cluster,or center of the synapse,include the TCR complex (TCR,CD3,and F1F1F1S1F1F1F10 chains),CD4 or CD8 coreceptors,and costimulatory molecules (CD28).The clustering of signaling molecules results in the phosphorylation of ITAMs on CD3 by CD4- or CD8-associated Lck.Integrins remain at the peripheral zone of the synapse and stabilize the binding of the T cell to the APC.LAT is a transmembrane adaptor molecule recruited to the synapse whose cytoplasmic tail forms part of a scaffold of signaling molecules.

All of the Following Are Early T Cell Events That