Which of the following events does NOT occur within germinal centers?

Question

Quizplus · Accepted Answer

V(D)J recombination to form functional Ig genes occurs only in developing B cells,mostly in the bone marrow.Germinal centers are sites of differentiation of mature B cells,in response to T cell-dependent protein antigens.The germinal center "reaction" begins with helper T cell signals delivered to B cells via CD40 ligand and cytokines.This results in B cell movement back into the follicle and brisk B cell proliferation of one or a few clones of B cells specific for an inciting antigen.The proliferating B cells undergo somatic mutation of the variable genes,at which point mutations are introduced that may alter the affinity of the encoded antibodies for their antigens.Antigens are displayed in limited concentrations on the surfaces of follicular dendritic cells in the germinal center,and only B cells whose high-affinity Ig receptors can bind these antigens are selected to survive.Some of these cells become antibody-secreting cells,and others become memory B cells.

Which of the Following Events Does NOT Occur Within Germinal