Which one of the following is NOT a mechanism of T cell tolerance?
A)Inhibition of T cell activation by interleukin-12 from regulatory T cells.
B)Apoptosis induced by Fas ligand binding to Fas.
C)Anergy induced by B7-1 or B7-2 binding to CTLA-4.
D)Anergy induced by peptide-major histocompatibility complex (MHC)binding to T cell receptors (TCRs)without B7-1 or B7-2 binding to CD28.
E)TCR-mediated up-regulation of Bim or similar pro-apoptotic proteins.

Question

Quizplus · Accepted Answer

Regulatory T lymphocytes secrete transforming growth factor-F1F1F1S1F1F1F10 and interleukin (IL)-10,which act as immunosuppressive cytokines.IL-12 is a proinflammatory cytokine produced mainly by activated macrophages and dendritic cells;it promotes effector T cell differentiation and interferon-F1F1F1S1F1F1F10 production.T cell anergy can be induced by lack of B7-costimulation or by B7-binding to CTLA-4.Activation-induced cell death is apoptosis induced by Fas signals or by T cell receptor signals that enhance Fas-independent pro-apoptotic pathways in T cells.

Which One of the Following Is NOT a Mechanism of T