Which of the following terms best describes the mechanism by which effector T cells are deleted by repeated stimulation by persistent antigen?
A)Passive cell death
B)Central tolerance
C)Peripheral tolerance
D)Death by neglect
E)Activation-induced cell death

Question

Quizplus · Accepted Answer

After repeated stimulation by antigen during an immune response,effector T cells undergo apoptosis because the Fas-Fas ligand pathway is up-regulated and because pro-apoptotic proteins,such as Bim,are up-regulated.The net effect is that the population of mature lymphocytes is depleted of T cells specific for the antigen that induced repeated stimulation.This is known as activation-induced cell death and serves to clear effector T cells close to the end of an immune response,as well as to delete autoreactive T cells.Passive cell death refers to a loss of survival stimuli resulting in the intrinsic,or mitochondrial,pathway of apoptosis.Peripheral tolerance refers to the deletion or anergy induced in self-reactive lymphocytes in nongenerative organs (e.g. ,not the bone marrow or the thymus).Death by neglect is the fate of developing T cells in the thymus,whose T cell receptors do not bind any self MHC-peptide complexes.

Which of the Following Terms Best Describes the Mechanism by Which