Which one of the following factors generally favors tolerance to an antigen and not stimulation of an immune response?
A)High doses of antigen
B)Short-lived persistence of antigen
C)Cutaneous portal of entry
D)Presence of adjuvant
E)Costimulator expression on antigen-presenting cells

Question

Quizplus · Accepted Answer

High doses of antigens favor thymic deletion (if the antigen is a self-antigen)or peripheral deletion by activation-induced cell death.Antigens that induce immune responses are often present for short durations,enter through skin,and are associated with adjuvants that enhance antigen presentation and costimulatory molecule expression.

Which One of the Following Factors Generally Favors Tolerance to an Antigen