Which of the following statements about B cell tolerance is NOT true?
A)Negative signaling induced by monovalent antigens is a mechanism of central B cell tolerance.
B)Exclusion of B cells from follicles is a mechanism of peripheral B cell tolerance.
C)Functional anergy is a mechanism of peripheral B cell tolerance.
D)Receptor editing is a mechanism of central B cell tolerance.
E)Down-regulation of antigen receptor expression is a mechanism of central B cell tolerance.

Question

Quizplus · Accepted Answer

Central B cell tolerance is most likely to be induced by multivalent antigens that can cross-link multiple membrane Ig molecules and thereby deliver strong signals to developing B cells. This may result in B cell apoptosis, antigen receptor down-regulation, or receptor editing, whereby V(D)J recombination is reinitiated and light chain gene usage is altered. In peripheral B cell tolerance, B cells may become anergic or they may be excluded from entry into follicles, owing in part to failure of expression of CCR5 chemokine receptors.

Which of the Following Statements About B Cell Tolerance Is