All of the following are effector mechanisms of antibody-mediated disease EXCEPT:
A) Opsonization and phagocytosis of cells
B) Fas-dependent apoptosis of cells
C) Complement- and Fc receptor-mediated inflammation and tissue injury
D) Antibody stimulation of cell surface receptors in the absence of the physiologic ligands
E) FcɛR crosslinking

Question

Quizplus · Accepted Answer

Fas-dependent apoptosis is a regulatory mechanism in T cell-mediated responses and may be involved in T cell-mediated damage to other cells, but the Fas pathway is not stimulated by antibodies
Antibody-mediated (types I to III) hypersensitivity diseases involve four main effector mechanisms: (1) IgE coats mast cells and links the presence of allergens with mast cell activation and release of inflammatory mediators; (2) antibody-mediated opsonization of cells and activation of complement promotes phagocytosis of cells through phagocyte Fc or C3 receptors; (3) antibody binding to tissues can promote recruitment of leukocytes via binding to Fc receptors on leukocytes or by activation of complement with release of chemotactic byproducts; and (4) autoantibodies specific for cell surface receptors either stimulate receptor activity in the absence of the physiologic ligand or inhibit binding of physiologic ligands to their receptors.

All of the Following Are Effector Mechanisms of Antibody-Mediated Disease