In which of the following conditions would you be LEAST likely to see a robust delayed-type hypersensitivity (DTH)response to a Candida antigen skin challenge?
A)X-linked agammaglobulinemia
B)DiGeorge syndrome
C)Selective IgA deficiency
D)Common variable immunodeficiency
E)Chronic granulomatous disease

Question

Quizplus · Accepted Answer

A delayed-type hypersensitivity (DTH)response is an immune reaction in which T cell-dependent macrophage activation and inflammation cause tissue injury.The severity of the reaction to the subcutaneous injection of antigen is used as an assay for cell-mediated immunity.A deficient cutaneous DTH response to common microbial antigens,such as Candida antigens,suggests a T cell immunodeficiency.DiGeorge syndrome is a selective T cell deficiency caused by a congenital malformation that results in defective development of the thymus and other embryologically associated structures.In contrast,X-linked agammaglobulinemia,selective IgA deficiency,and common variable immunodeficiency are B cell immunodeficiencies.Chronic granulomatous disease is a congenital disorder in which phagocytes cannot generate free radicals and kill ingested microbes.

In Which of the Following Conditions Would You Be LEAST