Which of the following statements about induction or maintenance of T cell tolerance is NOT true?
A) Central tolerance is induced when immature developing T cells in bone marrow or thymus encounter self antigens.
B) Peripheral T cell tolerance results when mature naive T cells recognize antigens without adequate B7-1- or B7-2-mediated costimulation.
C) Peripheral T cell tolerance results when T cells recognize antigen in the setting of an innate immune response to the antigen.
D) Peripheral T cell tolerance to some antigens is induced when mature T cells recognize antigen and bind B7-1 or B7-2 via the inhibitory CTLA-4 receptor.
E) Peripheral T cell tolerance to an antigen may be induced by persistent and repeated stimulation of lymphocytes by that antigen in tissues.
Correct Answer:
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Q2: For each feature of self-tolerance described in
Q3: Failure of self-tolerance is the cause of
Q4: For each feature of self-tolerance described in
Q5: The AIRE protein is expressed by thymic
Q6: Immunologic tolerance is defined as:
A)The removal of
Q7: For each feature of self-tolerance described in
Q8: For each feature of self-tolerance described in
Q9: CTLA-4,expressed by regulatory T cells and activated
Q10: For each feature of self-tolerance described in
Q11: For each feature of self-tolerance described in
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