Which individuals are most susceptible to Tay-Sachs disease?

Question

Quizplus · Accepted Answer

Tay-Sachs disease is most common among European Jews. It is a genetic disease that is caused by the absence or insufficient levels of an enzyme called Hexosaminidase A, which is essential in breaking down a fatty substance known as ganglioside GM2 that accumulates in the nervous system. This leads to progressive damage to the central nervous system and ultimately results in death. While Tay-Sachs can occur in any population, it is most frequently observed in individuals of Ashkenazi Jewish descent.

Which Individuals Are Most Susceptible to Tay-Sachs Disease