The major difference in the anatomy of ray- and lobe-finned fish is that in the former, limb bones were articulated to the backbone and used in locomotion.

Question

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The major difference lies in their fin structure: ray-finned fish have fins supported by long, flexible rays, while lobe-finned fish have fins with a bone structure similar to the limbs of terrestrial vertebrates, not specifically in how limb bones were articulated to the backbone for locomotion.

The Major Difference in the Anatomy of Ray- and Lobe-Finned