The monozygotic Genain quadruplets are one of the most famous case studies of schizophrenia, as the four sisters had very different outcomes. Myra had one psychotic episode, got married, had a successful career, and was never hospitalized. Nora and Iris were hospitalized repeatedly, never married, and had unstable work histories. Hester showed signs of schizophrenia before her teen years, never graduated from high school, and lived most of her life in hospitals and supervised environments. What would explain why the four girls had some symptoms of schizophrenia but had clear differences in symptom severity?
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