In the first step of a solid-phase peptide synthesis, an Fmoc-amino acid reacts with a chloromethyl group on the resin. (a) Draw a curved-arrow mechanism and draw the amino acid linked to the resin. (b) explain why a Fmoc group is needed and how to remove it.

Question

Quizplus · Accepted Answer

The Answer of In the first step of a solid-phase peptide synthesis, an Fmoc-amino acid reacts with a chloromethyl group on the resin. (a) Draw a curved-arrow mechanism and draw the amino acid linked to the resin. (b) explain why a Fmoc group is needed and how to remove it.

In the First Step of a Solid-Phase Peptide Synthesis, an Fmoc-Amino