Could cancer cells be selectively targeted by using antibodies recognizing a tumor-specific protein marker? Researchers grafted human cancerous cells onto 20 healthy adult mice and then randomly assigned 10 of these mice to be treated with tumor-specific antibodies. They found that only 1 of the 10 mice treated with antibodies developed metastases (i.e., new cancer growths), whereas all 10 of the 10 mice in the control group developed metastases. What is the plus four estimate for the proportion of mice developing metastases in the control group?

Question

Quizplus · Accepted Answer

The plus four estimate adds 2 successes and 2 failures to the sample. For the control group, this means 12 total mice (10 original + 2 added) and 12 successes (10 original + 2 added), resulting in a proportion of 12/12 = 0.9167.

Could Cancer Cells Be Selectively Targeted by Using Antibodies Recognizing