The progression from metaphase to anaphase is triggered by
A) activation of protein kinases by MPF.
B) ubiquitin-mediated proteolysis of key proteins.
C) binding of an inhibitory protein to MPF.
D) depolymerization of the mitotic spindle.

Question

Quizplus · Accepted Answer

The progression from metaphase to anaphase is triggered by ubiquitin-mediated proteolysis of key proteins. Specifically, the cohesin proteins that hold sister chromatids together are targeted for degradation by the APC/C ubiquitin ligase complex, thus allowing the chromatids to separate and move towards opposite poles of the cell.

The Progression from Metaphase to Anaphase Is Triggered by