A researcher generated a mutant SH2-containing protein such that it binds tyrosine and phosphotyrosine with equal affinity. As a result, MEK activity would be expected to
A) increase with ligand binding-induced dimerization.
B) remain the same with receptor dimerization and autophosphorylation.
C) decrease due to changes in Raf activation.
D) decrease due to allosteric inhibition of SH2-domain binding.
Correct Answer:
Verified
Q32: CREB is activated by
A) cAMP binding in
Q33: Which statement correctly describes how protein kinase
Q34: Activated CREB protein
A) phosphorylates protein phosphatase 1,
Q35: The first step in growth factor pathway
Q36: MAP kinase is an abbreviation for _
Q38: Binding of integrins to the extracellular matrix
Q39: Mutated oncogenic Ras proteins usually
A) cleave GTP
Q40: Ras is a membrane-bound _ when
Q41: MAP kinase signal cascades are often organized
Q42: The RAS guanine nucleotide-binding protein is activated
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