The TGF-$\beta$Smad pathway is similar to JAK/STAT signaling in that a protein kinase associated with a receptor directly phosphorylates and activates a transcription factor. However, the receptors for transforming growth factor beta (TGF-$\beta$) and related polypeptides are protein kinases that phosphorylate _______, rather than _______, residues on their substrate proteins.

Question

Quizplus · Accepted Answer

The TGF-β/Smad pathway involves protein kinases associated with TGF-β receptors that directly phosphorylate serine or threonine residues on their substrate proteins, while JAK/STAT signaling involves protein kinases associated with cytokine receptors that directly phosphorylate tyrosine residues.

The TGF- β\betaβ Smad Pathway Is Similar to JAK/STAT Signaling in That a in That

The TGF- $\beta$ Smad Pathway Is Similar to JAK/STAT Signaling in That a in That