G protein-coupled receptors are important molecules involved in signal transduction. Which statement about G protein-coupled receptors is true?

Question

Quizplus · Accepted Answer

G protein-coupled receptors generally contain seven membrane-spanning helices, which form a structural domain called heptahelical or seven-transmembrane domain. They are activated by various ligands, including neurotransmitters, hormones, and sensory stimuli, and signal through a complex network of intracellular effector proteins mediated by G proteins. They bind guanine nucleotides only indirectly, through their interaction with G proteins. They do not specifically bind adenine nucleotides. Steroid hormones act on intracellular receptors, which are not G protein-coupled.

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