Collagen fibrils form extracellularly and not intracellularly, even though their components are synthesized within the cell and transported to the cell surface via the Golgi. Which statement explains why this happens?
A) Type I procollagen is synthesized with nonhelical segments at each end of the polypeptide chain, limiting their ability to form collagen fibrils in cells.
B) Procollagen is soluble and small enough to fit within the intracellular transport machinery.
C) Type I collagen consists of about 1000 amino acids or 330 Gly-X-Y repeats.
D) Type I procollagen contains hydroxylated proline and lysine residues that prevent polypeptide chain formation within the cell.

Question

Quizplus · Accepted Answer

Nonhelical segments at each end of the polypeptide chain limit the ability of type I procollagen to form collagen fibrils within cells, leading to extracellular fibril formation.

Collagen Fibrils Form Extracellularly and Not Intracellularly, Even Though Their