Some proteins destined for insertion into the inner membrane are transported from the matrix compartment.

Question

Quizplus · Accepted Answer

Inner membrane proteins have to cross the outer membrane first to reach the intermembrane space, and then they are transported further to the inner membrane. Some of these proteins are synthesized in the cytosol, while others (like those encoded by mtDNA) are synthesized in the mitochondrial matrix. These matrix-synthesized proteins have to be transported across the inner membrane to reach their final destination. They use specific transport pathways that involve protein complexes in the inner membrane, such as the TIM (translocase of the inner membrane) and the TOM (translocase of the outer membrane) complexes.

Some Proteins Destined for Insertion into the Inner Membrane Are