The major function of the hydrophobic sequence at the amino terminals of proteins that are to be secreted from eukaryotic cells is to target those proteins to the rough ER.

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The hydrophobic sequence, also known as the signal peptide, serves as a recognition signal for the protein to be transported to the endoplasmic reticulum (ER) for processing and eventual secretion. Once in the ER, the hydrophobic sequence is recognized by the translocon, a protein complex that facilitates the transport of the protein through the membrane and into the ER lumen. Therefore, the hydrophobic sequence plays a critical role in targeting secreted proteins to the correct cellular compartment.

The Major Function of the Hydrophobic Sequence at the Amino