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Investigators Discovered Two Eukaryotic Regulatory Proteins That Control Expression of the Same

Question 22

Multiple Choice

Investigators discovered two eukaryotic regulatory proteins that control expression of the same gene. Their findings are summarized in the table below. Which hypothesis is most consistent with these findings?  Binding  specificity of  protein to DNA  Number of  domains in  protein  Protein  molecular  weight  Effect on  transcription  Regulatory  protein I  CACGTG 2130kDa Stimulates  Regulatory  protein II  CACGTG 170kDa Represses \begin{array} { | c | c | c | c | c | } \hline & \begin{array} { c } \text { Binding } \\\text { specificity of } \\\text { protein to DNA }\end{array} & \begin{array} { c } \text { Number of } \\\text { domains in } \\\text { protein }\end{array} & \begin{array} { c } \text { Protein } \\\text { molecular } \\\text { weight }\end{array} & \begin{array} { c } \text { Effect on } \\\text { transcription }\end{array} \\\hline \begin{array} { c } \text { Regulatory } \\\text { protein I }\end{array} & \text { CACGTG } & 2 & 130 \mathrm { kDa } & \text { Stimulates } \\\hline \begin{array} { c } \text { Regulatory } \\\text { protein II }\end{array} & \text { CACGTG } & 1 & 70 \mathrm { kDa } & \text { Represses } \\\hline\end{array}


A) Both regulatory proteins block the binding of activators to DNA.
B) Both regulatory proteins affect transcription by binding to mediator proteins.
C) Regulatory protein I blocks the binding of activators to DNA, whereas regulatory protein II affects transcription by binding to mediator proteins.
D) Regulatory protein I affects transcription by binding to mediator proteins, whereas regulatory protein II blocks the binding of activators to DNA.

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