A research lab working with mouse cells characterized three mutant cell lines summarized in the table below. Which of these is most likely to contain a mutated form of P-TEFb? Explain.
$$\begin{array} { | c | c | c | c | }
\hline \begin{array} { c }
\text { Mutant } \
\text { cell line }
\end{array} & \text { Transcription initiation } & \text { Transcription elongation } & \text { Histone modification } \
\hline \mathrm { X } & \text { Functions normally } & \begin{array} { c }
\text { Unable to make } \
\text { transcripts larger than } 50 \
\text { nucleotides }
\end{array} & \text { Functions normally } \
\hline \mathrm { Y } & \begin{array} { c }
\text { Lost sensitivity to a } \
\text { transcriptional repressor }
\end{array} & \text { Functions normally } & \text { Functions normally } \
\hline \mathrm { Z } & \text { Functions normally } & \text { Functions normally } & \begin{array} { c }
\text { Lost ability to } \
\text { deacetylate histones }
\end{array} \
\hline
\end{array}$$

Question

A research lab working with mouse cells characterized three mutant cell lines summarized in the table below. Which of these is most likely to contain a mutated form of P-TEFb? Explain.
 $$\begin{array} { | c | c | c | c | } 
\hline \begin{array} { c } 
\text { Mutant } \
\text { cell line }
\end{array} & \text { Transcription initiation } & \text { Transcription elongation } & \text { Histone modification } \
\hline \mathrm { X } & \text { Functions normally } & \begin{array} { c } 
\text { Unable to make } \
\text { transcripts larger than } 50 \
\text { nucleotides }
\end{array} & \text { Functions normally } \
\hline \mathrm { Y } & \begin{array} { c } 
\text { Lost sensitivity to a } \
\text { transcriptional repressor }
\end{array} & \text { Functions normally } & \text { Functions normally } \
\hline \mathrm { Z } & \text { Functions normally } & \text { Functions normally } & \begin{array} { c } 
\text { Lost ability to } \
\text { deacetylate histones }
\end{array} \
\hline
\end{array}$$

Quizplus · Accepted Answer

The Answer of A research lab working with mouse cells characterized three mutant cell lines summarized in the table below. Which of these is most likely to contain a mutated form of P-TEFb? Explain.
 $$\begin{array} { | c | c | c | c | } 
\hline \begin{array} { c } 
\text { Mutant } \
\text { cell line }
\end{array} & \text { Transcription initiation } & \text { Transcription elongation } & \text { Histone modification } \
\hline \mathrm { X } & \text { Functions normally } & \begin{array} { c } 
\text { Unable to make } \
\text { transcripts larger than } 50 \
\text { nucleotides }
\end{array} & \text { Functions normally } \
\hline \mathrm { Y } & \begin{array} { c } 
\text { Lost sensitivity to a } \
\text { transcriptional repressor }
\end{array} & \text { Functions normally } & \text { Functions normally } \
\hline \mathrm { Z } & \text { Functions normally } & \text { Functions normally } & \begin{array} { c } 
\text { Lost ability to } \
\text { deacetylate histones }
\end{array} \
\hline
\end{array}$$

A Research Lab Working with Mouse Cells Characterized Three Mutant