Which rationale best describes the ability of an enhancer to mediate transcription from very distant sites?
A) Looping of the DNA can occur, allowing the transcription factor to come into proximity of the RNA polymerase.
B) When needed, enhancers are spliced into a region closer to the promoter.
C) They are recognized by RNA polymerase, which binds to the enhancers and then slides down the promoter toward the gene.
D) All of the above
Correct Answer:
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