The human genes that convey a susceptibility to hereditary nonpolyposis colorectal cancer are genes coding proteins involved in the DNA repair mechanism called
A) mismatch repair.
B) nucleotide-excision repair.
C) photoreactivation.
D) transcription-coupled repair.

Question

Quizplus · Accepted Answer

The genes that confer susceptibility to hereditary nonpolyposis colorectal cancer are those involved in DNA mismatch repair. These genes include MLH1, MSH2, MSH6, PMS1, and PMS2, which encode proteins involved in recognizing and repairing errors that occur during DNA replication. Nucleotide-excision repair is a separate pathway involved in repairing DNA damage caused by UV radiation, while photoreactivation and transcription-coupled repair are other mechanisms involved in repairing DNA damage.

The Human Genes That Convey a Susceptibility to Hereditary Nonpolyposis