Christian Anfinsen and colleagues showed in the 1950s that proteins contain all the information to spontaneous fold into an active enzyme. Yet sixty years later, we can still not predict the three-dimension shape of a protein from its amino acid sequence.

Question

Quizplus · Accepted Answer

Although we know that the information for protein folding is contained in the amino acid sequence, predicting the precise three-dimensional shape is still a challenge due to the complexity of the process and the large number of possible conformations.

Christian Anfinsen and Colleagues Showed in the 1950s That Proteins