What was a major economic repercussion of the fall of the Byzantine empire to the Ottomans?

Question

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The fall of the Byzantine Empire to the Ottomans led to the severing of trade routes between Western Europe and Asia, which had major economic repercussions for both regions. This disruption in trade affected the flow of goods, ideas, and wealth, leading to a decline in economic activity and growth for centuries to come. Options A, B, and D are not accurate as they do not reflect the impact of the fall of the Byzantine Empire on trade and economic activity.

What Was a Major Economic Repercussion of the Fall of the Byzantine