A reduction in the expression of which of the following proteins on the surface of monocytes could explain the exercise-induced depression of both innate and acquired immune cell functions?

Question

Quizplus · Accepted Answer

TLR4 is a key receptor involved in recognizing bacterial products and activating the immune response. Exercise has been shown to downregulate the expression of TLR4 on the surface of monocytes, which could explain the exercise-induced depression of immune cell functions. CD14 and CD16 are also surface proteins on monocytes, but there is no clear evidence that their reduction in expression would explain the observed immune depression. TLR9 is involved in recognizing viral DNA and is not likely to be affected by exercise-induced changes. Therefore, the correct answer is C) TLR4.

A Reduction in the Expression of Which of the Following