Exercising in state of glycogen depletion increases plasma cortisol and IL-6 concentrations, which, in turn, increases total leukocyte numbers.

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This statement is true. Exercising in a state of glycogen depletion can cause an increase in plasma cortisol and IL-6 concentrations, which have been shown to increase the number of leukocytes in the blood. This is thought to be a normal response to the stress of glycogen depletion and exercise.

Exercising in State of Glycogen Depletion Increases Plasma Cortisol and IL-6