During Moderate- to High-Intensity Exercise, Why Is the Bioavailability of Most

During moderate- to high-intensity exercise, why is the bioavailability of most drugs altered?

A) Serum proteins bind drugs tighter - with higher affinity
B) Drugs are taken up faster in the stomach
C) Blood flow decreases to the liver and kidneys
D) Metabolism in muscle tissue increases significantly
E) The rate of sweat formation increases significantly