A Patient Who Is HIV-Positive Begins Therapy with the Fixed-Dose

A patient who is HIV-positive begins therapy with the fixed-dose combination nucleoside reverse transcriptase inhibitor (NRTI) Combivir (lamivudine/zidovudine) twice daily. The patient is in the clinic for follow-up 1 week after initiation of therapy and reports having nausea. The patient's creatinine clearance is 40 mL/minute. Based on these findings, the nurse will perform which action?

A) Instruct the patient to take the medication 60 minutes prior to meals.
B) Notify the provider to discuss dose adjustments.
C) Request an order for once-daily dosing of this medication.
D) Suggest that the patient increase fluid intake.