These antidepressants inhibit the brain's reuptake of several neurotransmitters, primarily norepinephrine and serotonin, thus prolonging activity of these chemicals at synapses. a. selective serotonin reuptake inhibitors

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Tricyclic antidepressants work by inhibiting the reuptake of both norepinephrine and serotonin, thereby increasing their levels and activity in the brain. This contrasts with selective serotonin reuptake inhibitors (SSRIs) that specifically target serotonin reuptake. MAO inhibitors work by inhibiting the monoamine oxidase enzyme that breaks down neurotransmitters like serotonin and norepinephrine, and barbiturates are not antidepressants but are sedatives that affect the central nervous system.

These Antidepressants Inhibit the Brain's Reuptake of Several Neurotransmitters, Primarily