Increases in plasma holotranscobalamin TCII concentrations provide an indication of vitamin B₁₂ absorption.

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Holotranscobalamin (also known as active B12) is the biologically active form of vitamin B12 that is available for tissues to use. An increase in plasma holotranscobalamin concentrations indicates that dietary vitamin B12 has been absorbed and taken up by cells. This makes it a useful indicator of vitamin B12 absorption. TCII (transcobalamin II) is a protein that binds to vitamin B12 and allows it to be transported throughout the body. Therefore, an increase in plasma holotranscobalamin TCII concentrations indicates that vitamin B12 is being transported and used by cells.

Increases in Plasma Holotranscobalamin TCII Concentrations Provide an Indication of Vitamin