A genetic polymorphism that decreases the activity of N5,N10 methylene tetrahydrofolate reductase has been identified.This would cause ____.

Question

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N5,N10 methylene tetrahydrofolate reductase is involved in converting homocysteine to methionine, and a decrease in its activity would lead to an increase in homocysteine levels. This is associated with an increased risk for cardiovascular disease. Choices C and D are incorrect because megaloblastic anemia is actually associated with a deficiency in folate metabolism, and a decrease in N5,N10 methylene tetrahydrofolate reductase activity would not result in a decreased risk for heart disease. Choice A may seem tempting, but an accumulation of 5-methyl THF is not a known effect of this particular genetic polymorphism.

A Genetic Polymorphism That Decreases the Activity of N5,N10 Methylene