The major consequence of degeneration of substantia nigra cells is a decrease in _______ input into the striatum, which results in less _______ of the globus pallidus and greater tonic inhibition of the _______, reducing _______ input to the cortex.

Question

Quizplus · Accepted Answer

The degeneration of substantia nigra cells, as seen in Parkinson's disease, leads to a decrease in dopamine input into the striatum. This results in less inhibition of the globus pallidus, which in turn increases tonic inhibition of the thalamus, ultimately reducing excitatory input to the cortex.

The Major Consequence of Degeneration of Substantia Nigra Cells Is