Familial cases of AD (known as autosomal dominant Alzheimer's disease) are caused by mutations of _______ genes, including _______, and make up _______ of cases.

Question

Quizplus · Accepted Answer

Familial cases of AD are caused by deterministic genes, including presenilin-1, presenilin-2, and amyloid precursor protein, and make up 5-10% of cases. Choice A is incorrect because presenilin-1 is a deterministic gene, not a risk gene, and familial cases make up more than 0.5% of cases. Choice B is incorrect because apolipoprotein E is a risk gene, not a deterministic gene, and it only accounts for a portion of sporadic cases. Choice D is incorrect because apolipoprotein E is not a deterministic gene, and familial cases make up a smaller percentage of cases than 15%.

Familial Cases of AD (Known as Autosomal Dominant Alzheimer's Disease)