Which hypothesis was developed after it was shown that the effects of high doses of ketamine are similar to symptoms of schizophrenia?

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The hypothesis that a major factor in schizophrenia is hypoactivity of the glutamatergic system, particularly NMDA receptor signaling, was developed after it was shown that the effects of high doses of ketamine (which is an NMDA receptor antagonist) are similar to symptoms of schizophrenia. This hypothesis is supported by a large body of research and has led to the development of new drugs aimed at modulating glutamatergic signaling as a potential treatment for schizophrenia.

Which Hypothesis Was Developed After It Was Shown That the Effects