In _______ withdrawal, mice that have been habituated to chronic THC are administered the CB₁ _______. A) precipitated; agonist WIN 55,212-2 B) precipitated; antagonist SR 141716A C) abrupt; agonist WIN 55,212-2 D) abrupt; antagonist SR 141716A

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Quizplus · Accepted Answer

The question is discussing THC withdrawal in mice, and specifically refers to the use of the drugs WIN 55,212-2 (an agonist) and SR 141716A (an antagonist). The term "habituated" suggests that the mice have become tolerant to the effects of chronic THC use. To induce withdrawal, they are given either an agonist or an antagonist. The correct answer is B, "precipitated; antagonist SR 141716A," because precipitated withdrawal refers to the abrupt cessation or blockade of drug use in animals, whereas agonist-induced withdrawal suggests that the withdrawal is being induced by another drug that activates the same receptors as THC. Additionally, mice that have become habituated to THC are likely to experience withdrawal symptoms if they are suddenly denied access to the drug, supporting the idea that the withdrawal in this case is precipitated rather than abrupt. Finally, SR 141716A is an antagonist of CB1 receptors, which are the primary receptor targets of THC in the brain. Therefore, administering this drug to habituated mice would be expected to precipitate withdrawal by blocking the actions of THC on these receptors.

In _______ Withdrawal, Mice That Have Been Habituated to Chronic