Which condition will produce the greatest psychostimulant effect, based on dopamine transporter (DAT) occupancy?

Question

Quizplus · Accepted Answer

IV administration of a drug will produce the greatest psychostimulant effect based on dopamine transporter (DAT) occupancy because it allows the drug to quickly and efficiently cross the blood-brain barrier and reach the brain. This results in a higher concentration of the drug in the brain, leading to greater DAT occupancy and a stronger psychostimulant effect. Intranasal administration may provide faster onset of effects but may not result in as high of a concentration of the drug in the brain. 30% of transporters affected by the drug and low baseline dopamine levels may still result in a psychostimulant effect but not to the extent of IV administration.

Which Condition Will Produce the Greatest Psychostimulant Effect, Based on Dopamine