D₁ receptor knockout mice do not self-administer cocaine, which suggests that

Question

Quizplus · Accepted Answer

Knockout of the D₁ receptor prevents cocaine self-administration, suggesting that blockade of this transporter plays a key role in cocaine's reinforcing action. This implies that dopamine is still important for cocaine's reinforcing effects, but that its reuptake via this specific transporter is necessary for the drug's rewarding properties. Therefore, option A is incorrect. Option C is also incorrect because the transporter is not mutant; rather, it has been knocked out. Finally, option D is incorrect because cocaine reward and reinforcement are often used interchangeably, but they are distinct processes.

D1 Receptor Knockout Mice Do Not Self-Administer Cocaine, Which Suggests

D₁ Receptor Knockout Mice Do Not Self-Administer Cocaine, Which Suggests