Chronic cocaine use results in diminished _______ activity, including down-regulation of neurotransmitter synthesis, release, and neurotransmitter transporter and receptor levels.

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Chronic cocaine use results in diminished striatal dopaminergic activity, including down-regulation of neurotransmitter synthesis, release, and neurotransmitter transporter and receptor levels. This leads to a decreased ability to experience pleasure and reward, promoting the cycle of addiction.

Chronic Cocaine Use Results in Diminished _______ Activity, Including Down-Regulation