Therapeutic doses of methylphenidate _______ DATs in the striatum and NETs in the frontal cortex, thereby _______ the level of both DA and NE in the extracelluar fluid.

Question

Quizplus · Accepted Answer

Therapeutic doses of methylphenidate (Ritalin) block the reuptake of dopamine transporters (DATs) in the striatum and norepinephrine transporters (NETs) in the frontal cortex, thereby increasing the levels of both dopamine (DA) and norepinephrine (NE) in the extracellular fluid. This is why methylphenidate is classified as a dopamine/norepinephrine reuptake inhibitor (DNRI).

Therapeutic Doses of Methylphenidate _______ DATs in the Striatum and NETs